Our paper K29-linked ubiquitin signaling regulates proteotoxic stress response and cell cycle is online. This is a collaboration work with Tony Kossiakoff lab at UChicago, Lei Liu lab at THU, and Jingyi Fei lab at UChicago. A synthetic antigen binding reagent (sAB) that specifically recognizes K29-linked ubiquitin was developed and characterized. K29-linked polyubiquitin is quite abundant in vivo but the function of this particular linkage remains to be elucidated. Using the sAB as a tool, we discovered that this type of ubiquitin chain is involved in proteotoxic stress response and cell cycle regulation. Further investigations are required to decypher this intriguing ubiquitin code.

Also check out the News & Views on nature chemical biology. Again, thank all the wonderful collaborators and congratulations to Yuanyuan, Qingyun, and Satchal!