As a structural biology lab, we are interested in understanding human diseases at molecular level. In particular, we focus on macromolecules involved in protein aggregation and neurodegenerative diseases, such as Alzheimer’s and Parkinson’s diseases. We study not only the protein aggregates that cause the diseases, but also the proteins that are responsible for clearing the aggregates in a normal situation. We want to gain insights into the molecular architectures of the proteins, their complexes, and their aggregates so that the molecular mechanisms can be elucidated. Once we understand the mechanism, new approaches can be developed to tackle the diseases.
There are two major techniques used in the lab: X-ray crystallography and cryo-electron microscopy, both of which are capable of revealing atomic structures of macromolecules. While actively using the techniques to determine molecular structures, we are also keen on developing new computational methods to improve them. Specifically, we want to extract dynamic information from the data so that a molecular movie can be reconstructed beyond the static snapshots of the molecules. To learn more about the techniques, check out the resource page.
Specific projects will be updated over the time. Stay tuned!