Selected Publications

* equal contribution

All Publications

  1. The primed SNARE-complexin-synaptotagmin complex for neuronal exocytosis.

    Zhou Q*, Zhou P*, Wang AL, Wu D, Zhao M, Südhof TC, Brunger AT.
    Nature. (2017). 548(7668):420-5.

  2. Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18.

    Lai Y, Choi UB, Leitz J, Rhee HJ, Lee C, Altas B, Zhao M, Pfuetzner RA, Wang AL, Brose N, Rhee J, Brunger AT.
    Neuron. (2017). 95:591-607.

  3. Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex.

    Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Zhou Q, Zhao M, Brewster AS, Michels-Clark T, Holton JM, Sauter NK, Weis WI, Brunger AT.
    Elife. (2016). 5:e18740.

  4. N-terminal domain of complexin independently activates calcium-triggered fusion.

    Lai Y, Choi UB, Zhang Y, Zhao M, Pfuetzner RA, Wang AL, Diao J, Brunger AT.
    Proc Natl Acad Sci U S A. (2016). 113(32):E4698-707.

  5. Complexin induces a conformational change at the membrane-proximal C-terminal end of the SNARE complex.

    Choi UB, Zhao M, Zhang Y, Lai Y, Brunger AT.
    Elife. (2016). 5:e16886.

  6. Ketones block amyloid entry and improve cognition in an Alzheimer's model.

    Yin JX, Maalouf M, Han P, Zhao M, Gao M, Dharshaun T, Ryan C, Whitelegge J, Wu J, Eisenberg D, Reiman EM, Schweizer FE, Shi J.
    Neurobiol Aging. (2016). 39:25-37.

  7. Recent advances in deciphering the structure and molecular mechanism of the AAA+ ATPase N-ethylmaleimide Sensitive Factor (NSF).

    Zhao M, Brunger AT.
    J Mol Biol. (2016). 428(9 Pt B):1912-26.

  8. Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis.

    Zhou Q, Lai Y*, Bacaj T*, Zhao M*, Lyubimov AY, Uervirojnangkoorn M, Zeldin OB, Brewster AS, Sauter NK, Cohen AE, Soltis SM, Alonso-Mori R, Chollet M, Lemke HT, Pfuetzner RA, Choi UB, Weis WI, Diao J, Südhof TC, Brunger AT.
    Nature. (2015). 525(7567):62-7.

  9. ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes.

    Diao J, Liu R, Rong Y, Zhao M, Zhang J, Lai Y, Zhou Q, Wilz LM, Li J, Vivona S, Pfuetzner RA, Brunger AT, Zhong Q.
    Nature. (2015). 520(7548):563-6.

  10. Data Exploration Toolkit for serial diffraction experiments.

    Zeldin OB, Brewster AS, Hattne J, Uervirojnangkoorn M, Lyubimov AY, Zhou Q, Zhao M, Weis WI, Sauter NK, Brunger AT.
    Acta Crystallogr D Biol Crystallogr. (2015). 71(Pt 2):352-6.

  11. Mechanistic insights into the recycling machine of the SNARE complex.

    Zhao M*, Wu S*, Zhou Q, Vivona S, Cipriano DJ, Cheng Y, Brunger AT.
    Nature. (2015). 518(7537):61-7.

  12. Complexin-1 Enhances the On-Rate of Vesicle Docking via Simultaneous SNARE and Membrane Interactions.

    Diao J, Cipriano DJ, Zhao M, Zhang Y, Shah S, Padolina MS, Pfuetzner RA, Brunger AT.
    J Am Chem Soc. (2013). 135(41):15274-7.

  13. Studying protein-reconstituted proteoliposome fusion with content indicators in vitro.

    Diao J, Zhao M, Zhang Y, Kyoung M, Brunger AT.
    Bioessays. (2013). 35(7):658-65.

  14. Structure-based discovery of fiber-binding compounds that reduce the cytotoxicity of amyloid beta.

    Jiang L, Liu C, Leibly D, Landau M, Zhao M, Hughes MP, Eisenberg DS.
    Elife. (2013). 2:e00857.

  15. Amyloid beta-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity.

    Cheng PN, Liu C, Zhao M, Eisenberg D, Nowick JS.
    Nat Chem. (2012). 4(11):927-33.

  16. Direct visualization of the interaction between pilin and exopolysaccharides of Myxococcus xanthus with eGFP-fused PilA protein.

    Hu W, Yang Z, Lux R, Zhao M, Wang J, He X, Shi W.
    FEMS Microbiol Lett. (2012). 326(1):23-30.

  17. Atomic view of a toxic amyloid small oligomer.

    Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D.
    Science. (2012). 335(6073):1228-31.

  18. Out-of-register beta-sheets suggest a pathway to toxic amyloid aggregates.

    Liu C*, Zhao M*, Jiang L*, Cheng PN, Park J, Sawaya MR, Pensalfini A, Gou D, Berk AJ, Glabe CG, Nowick J, Eisenberg D.
    Proc Natl Acad Sci U S A. (2012). 109(51):20913-8.

  19. Molecular basis for amyloid-beta polymorphism.

    Colletier JP*, Laganowsky A*, Landau M*, Zhao M*, Soriaga AB*, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D.
    Proc Natl Acad Sci U S A. (2011). 108(41):16938-43.

  20. An approach to crystallizing proteins by metal-mediated synthetic symmetrization.

    Laganowsky A*, Zhao M*, Soriaga AB*, Sawaya MR, Cascio D, Yeates TO.
    Protein Sci. (2011). 20(11):1876-90.

  21. Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation.

    Zhao M, Cascio D, Sawaya MR, Eisenberg D.
    Protein Sci. (2011). 20(6):996-1004.

  22. High-resolution functional profiling of a gammaherpesvirus RTA locus in the context of the viral genome.

    Arumugaswami V, Sitapara R, Hwang S, Song MJ, Ho TN, Su NQ, Sue EY, Kanagavel V, Xing F, Zhang X, Zhao M, Deng H, Wu TT, Kanagavel S, Zhang L, Dandekar S, Papp J, Sun R.
    J Virol. (2009). 83(4):1811-22.

  23. The activation of lytic replication of Epstein-Barr virus by baculovirus-mediated gene transduction.

    Wang L, Shan L, Yin J, Zhao M, Su D, Zhong J.
    Arch Virol. (2006). 151(10):2047-53.

* equal contribution